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IonOptix MultiCell HTS Calcium and Contractility

IonOptix MultiCell

High Throughput Calcium and Contractility System

Characterizing excitation-contraction coupling and function in isolated myocytes can be challenging and time-consuming. While studies utilizing our standard Calcium and Contractility system have proved extremely valuable in the past, higher throughput is required to accommodate faster drug discovery and a growing motivation in basic research toward large scale, rapid data collection and analysis. Isolated myocytes display a high degree of functional variability, which can result in poor characterization of key parameters calculating myocyte dynamics. Acquiring data from a much greater number of myocytes provides the statistical power to characterize myocyte function with greater accuracy and confidence. In the pharmaceutical setting, this is a significant enhancement in phenotype quantification as it expedites assessment of drug efficacy/toxicity and greatly reduces costs by eliminating dangerous or marginal compounds.

The IonOptix MultiCell system offers fully-automated identification and mechanical phenotype quantification from hundreds of myocytes per hour. The MultiCell system includes both a fast x-y-z position-programmable scanning microscope as well as a novel image analysis method quantifying position, size, orientation, and dynamic characteristics of contraction-relaxation function. Additionally, the enclosed microscope maintains stable temperature while allowing full access for introduction of perfusion systems as well as electrical stimulation leads.

IonOptix turn-key systems have long been the gold standard for Calcium and Contractility measurements, offering everything needed for precise acquisition and analysis. Our MultiCell system does not compromise on any aspect of that system. Every detail of the measurement has been thoroughly considered to maintain the highest level of precision. Batch analysis enables fast, automated characterization from hundreds of cells, while still characterizing all of the same important parameters found in IonWizard’s core analysis. Double exponential fitting improves data fitting of calcium reuptake and subsequent tau calculations, an important parameter used to describe sodium-calcium exchange and SERCA activity. MultiCell offers the same thorough acquisition and analysis that our users expect from an IonOptix system at much higher acquisition and analysis rates.

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Note: This product is intended for research purposes only. It is not certified for clinical applications (including diagnostic purposes). Use of this product in uncertified applications is in violation of FDA regulations.


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