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Engineered skeletal muscle from electrically stimulated myoblast cells

Check out this video from researchers at the Department of Biomedical Engineering, Eindhoven University of Technology, in the Netherlands. Using an IonOptix Culture Pacing System, they show the development of engineered muscle tissue from electrically stimulated mouse myoblast cells (C2C12) grown in hydrogel constructs.  Electrical stimulation in culture aligns the cells in the constructs and promotes differentiation.

van der Schaft, D. W. J., van Spreeuwel, A. C. C., Boonen, K. J. M., Langelaan, M. L. P., Bouten, C. V. C., Baaijens, F. P. T. Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation. J. Vis. Exp. (73), e4267, doi:10.3791/4267 (2013).

*The Journal of Visualized Experiments (JoVE) is the first peer reviewed, PubMed indexed video journal. JoVE video publications offer labs the opportunity to publish complex laboratory techniques via video, providing a new and informative format to explore scientific methodology and results.