While studies utilizing IonOptix’ standard Calcium and Contractility systems have proven extremely valuable for many years, higher throughput is required to accommodate faster drug discovery and a growing motivation in basic research toward rapid, large scale data collection and analysis. Isolated myocytes display a high degree of functional variability, which can result in poor characterization of key parameters calculating myocyte dynamics. Acquiring data from a much greater number of myocytes provides the statistical power to characterize myocyte function with greater accuracy and confidence. In the pharmaceutical setting, this is a significant enhancement in phenotype quantification as it expedites assessment of drug efficacy/toxicity and greatly reduces costs by eliminating dangerous or marginal compounds.
Every technical detail of the MultiCell HTS has been thoroughly considered to maintain the highest level of precision while maintaining a positive and realistic user experience in the lab. Batch analysis enables fast, automated characterization from hundreds of cells, while still characterizing all of the same important parameters found in IonWizard’s core analysis. Double exponential fitting improves data fitting of calcium re-uptake and subsequent tau calculations, an important parameter used to describe sodium-calcium exchange and SERCA activity. MultiCell HTS offers the same thorough acquisition and analysis that our users expect from an IonOptix system at much higher acquisition and analysis rates.
As with all of our systems, we stand behind our products. When we install our complete systems we use your preparations to help get you started as quickly as possible. And when you need assistance we offer unlimited phone and email support for the lifetime of your system.