Membrane depolarization during the cardiac action potential initiates a large influx of calcium ions which then initiates the physical contraction of the cardiomyocyte. For decades, action potential measurements have been made independently of calcium and contractility measurements, the former predominantly relying on challenging, low-throughput patch clamping techniques. With the advent of new, less phototoxic and brighter voltage-sensitive dyes, we present a case study that demonstrates the feasibility of simultaneous voltage, calcium, and contractility recordings in single isolated cardiomyocytes using our MultiCell system.
Check out the case study in the link below.
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