HyperSwitch Hardware Manual
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G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.
ionoptix2019-11-09T22:16:04-05:00Raake, P. W., Vinge, L. E., Gao, E., Boucher, M., Rengo, G., Chen, X., DeGeorge Jr., B.R., Matkovich, S., Houser, S.R., Most, P., Eckhart, A.D., Dornll, G.W., and Koch, W. J. (2008). Circulation Research, 103(4), 413-422
Techniques and Best Practices for Cardiomyocyte Isolation
ionoptix2019-12-06T14:33:27-05:00Ronglih Liao and Davor Pavlovic discuss techniques for isolating myocytes using both traditional and Langendorff-free methodologies.
Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle.
ionoptix2019-11-09T22:20:21-05:00Misior, A. M., Deshpande, D. A., Loza, M. J., Pascual, R. M., Hipp, J. D., & Penn, R. B. (2009). American Journal of Respiratory Cell and Molecular Biology, 41(1), 24-39
Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle.
ionoptix2019-10-21T19:35:24-05:00Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Kramerova I, Kudryashova E, Wu B, Ottenheijm C, Granzier H, Spencer MJ Abstract: Calpain-3 (CAPN3) is a non-lysosomal cysteine protease that is necessary for normal muscle function, as mutations in CAPN3 result in an autosomal recessive form of limb girdle muscular dystrophy type 2A. To elucidate the biological roles of CAPN3 in skeletal muscle, we [...]
Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries.
ionoptix2019-10-22T18:25:49-05:00Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries. Zhao G, Adebiyi A, Blaskova E, Xi Q, Jaggar JH Abstract: Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) regulate diverse physiological functions, including contraction and proliferation. Three IP3R isoforms exist, but functional significance of these subtypes in arterial smooth muscle cells is unclear. Here, we investigated relative expression and physiological functions of IP3R isoforms in [...]
Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.
ionoptix2019-10-21T19:38:16-05:00Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Goldsworthy M, Hugill A, Freeman H, Horner E, Shimomura K, Bogani D, Pieles G, Mijat V, Arkell R, Bhattacharya S, Ashcroft FM, Cox RD Abstract: OBJECTIVES— To identify, map, clone, and functionally validate a novel mouse model for impaired glucose tolerance and insulin secretion. RESEARCH DESIGN AND METHODS— Haploinsufficiency of the insulin receptor and associated mild insulin [...]
Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.
ionoptix2019-10-22T18:25:28-05:00Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia. Jernigan NL, Walker BR, Resta TC Abstract: Recent evidence supports a prominent role for Rho kinase (ROK)-mediated pulmonary vasoconstriction in the development and maintenance of chronic hypoxia (CH)-induced pulmonary hypertension. Endothelin (ET)-1 contributes to the pulmonary hypertensive response to CH and recent studies by our laboratory and others indicate that pulmonary vascular reactivity following [...]
Maturation of intracellular calcium homeostasis in sheep pulmonary arterial smooth muscle cells.
ionoptix2019-11-09T22:28:40-05:00Goyal, R., Creel, K. D., Chavis, E., Smith, G. D., Longo, L. D., & Wilson, S. M. (2008). American Journal of Physiology-Lung Cellular and Molecular Physiology, 295(5)
Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes.
ionoptix2019-11-09T22:48:56-05:00Dobson, J. G., Shea, L. G., & Fenton, R. A. (2008). American Journal of Physiology-Heart and Circulatory Physiology, 295(6)