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In this Q&A video series, experts address your best questions and greatest challenges with regards to cardiomyocyte isolation, purification, culture and analysis.
The largest group of IonOptix users are investigators who study cardiac myocytes and want information about contractility parameters and the associated calcium transients. Our aim is to offer you a complete recording system for these experiments.
For dual excitation measurements with Fura-2, we offer two methods of collecting data, interleaved sampling and the interpolated numerator (or denominator) method.
Introduction This is a very, very basic introduction into the theory of fluorescence measurements and its practical implications as applied to experiments done using IonOptix equipment. For a thorough …
Overview Fluorescence signal quality is directly proportional to fluorescence light intensity (which is proportional to excitation light intensity, fluorescence yield of the fluorophore, and light …
Check out this video from researchers at the Department of Internal Medicine B, University Medicine Greifswald.
Raake, P. W., Vinge, L. E., Gao, E., Boucher, M., Rengo, G., Chen, X., DeGeorge Jr., B.R., Matkovich, S., Houser, S.R., Most, P., Eckhart, A.D., Dornll, G.W., and Koch, W. J. (2008). Circulation Research, 103(4), 413-422
Ronglih Liao and Davor Pavlovic discuss techniques for isolating myocytes using both traditional and Langendorff-free methodologies.
High-fat Diet-induced Obesity Leads to Resistance to Leptin-induced Cardiomyocyte Contractile Response. Jun Ren, Bang-Hao Zhu, David P. Relling, Lucy B. Esberg, Asli F. Ceylan-Isik Abstract: Levels of the obese gene product leptin are often elevated in obesity and may contribute to obesity-induced cardiovascular complications. However, the role of leptin in obesity-associated cardiac abnormalities has not been clearly defined. This study was designed to determine the influence of high-fat diet-induced obesity [...]
Overexpression of heat shock protein 27 protects against ischaemia/reperfusion-induced cardiac dysfunction via stabilization of troponin I and T. Lu XY, Chen L, Cai XL, Yang HT Abstract: Aims: Heat shock protein 27 (Hsp27) renders cardioprotection from ischaemia/reperfusion (I/R) injury, but little is known about its role in myofilaments. We proposed that increased expression of Hsp27 may improve post-ischaemic contractile dysfunction by preventing I/R-induced cardiac troponin I (cTnI) and troponin T [...]
