Culture Pacing
ISC Webmaster2019-11-10T19:56:46-05:00Engineered skeletal muscle from electrically stimulated myoblast cells Check out this video from researchers at the Department of Biomedical Engineering, Eindhoven University of Technology.
Rapid electrical stimulation induces early activation of kinase signal transduction pathways and apoptosis in adult rat ventricular myocytes.
ionoptix2019-10-22T17:43:24-05:00Rapid electrical stimulation induces early activation of kinase signal transduction pathways and apoptosis in adult rat ventricular myocytes. Kuramochi Y1, Guo X, Sawyer DB, Lim CC Abstract: Chronic tachycardia in patients and rapid pacing in animal models induce myocardial dysfunction and initiate a cascade of compensatory adaptations that are ultimately unsustainable, leading to ventricular enlargement and failure. The molecular pathogenesis during the early stages of tachycardia-induced cardiomyopathy, however, remains unclear. [...]
Induction of heat shock response protects the heart against atrial fibrillation.
ionoptix2019-10-22T17:44:44-05:00Induction of heat shock response protects the heart against atrial fibrillation. Brundel BJ, Shiroshita-Takeshita A, Qi X, Yeh YH, Chartier D, van Gelder IC, Henning RH, Kampinga HH, Nattel S Abstract: There is evidence suggesting that heat shock proteins (HSPs) may protect against clinical atrial fibrillation (AF). We evaluated the effect of HSP induction in an in vitro atrial cell line (HL-1) model of tachycardia remodeling and in tachypaced isolated [...]
Overexpression of Na+/Ca2+ exchanger alters contractility and SR Ca2+ content in adult rat myocytes.
ionoptix2019-10-22T17:47:44-05:00Overexpression of Na+/Ca2+ exchanger alters contractility and SR Ca2+ content in adult rat myocytes. Zhang XQ, Song J, Rothblum LI, Lun M, Wang X, Ding F, Dunn J, Lytton J, McDermott PJ, Cheung JY Abstract: The functional consequences of overexpression of rat heart Na+/Ca2+ exchanger (NCX1) were investigated in adult rat myocytes in primary culture. When maintained under continued electrical field stimulation conditions, cultured adult rat myocytes retained normal contractile [...]
Phosphorylation of phospholamban at threonine-17 reduces cardiac adrenergic contractile responsiveness in chronic pressure overload-induced hypertrophy.
ionoptix2019-10-22T17:48:24-05:00Phosphorylation of phospholamban at threonine-17 reduces cardiac adrenergic contractile responsiveness in chronic pressure overload-induced hypertrophy. Mills GD, Kubo H, Harris DM, Berretta RM, Piacentino V 3rd, Houser SR Abstract: Physiological hemodynamic stress, such as aerobic exercise, is intermittent and requires an increase in Ca2+-dependent contractility through sympathetic nervous system activation. Pathological hemodynamic stress, such as hypertension, is persistent and requires sustained increases in cardiac function. Over time, this causes left [...]
Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation.
ionoptix2019-11-09T22:34:07-05:00Brundel, B. J., Henning, R. H., Ke, L., Gelder, I. C., Crijns, H. J., & Kampinga, H. H. (2006). Journal of Molecular and Cellular Cardiology, 41(3), 555-562
Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle.
ionoptix2019-11-09T22:43:36-05:00Nedachi, T., Fujita, H., & Kanzaki, M. (2008). American Journal of Physiology-Endocrinology and Metabolism, 295(5)
Accelerated de novo sarcomere assembly by electric pulse stimulation in C2C12 myotubes.
Andy Henton2019-11-09T22:53:38-05:00Fujita, H., Nedachi, T., & Kanzaki, M. (2007). Experimental Cell Research, 313(9), 1853-1865
Effects of sarcoplasmic reticulum Ca2+-ATPase overexpression in postinfarction rat myocytes.
ionoptix2019-11-09T22:57:02-05:00Ahlers, B. A., Song, J., Wang, J., Zhang, X., Carl, L. L., Tadros, G. M., Rothblum, L.I., and Cheung, J. Y. (2005). Journal of Applied Physiology, 98(6), 2169-2176