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35 mm Microscope Chamber System The 35 mm Microscope Chamber System is a newly designed chamber system to perfuse and stimulate cardiac myocytes that are studied on the microscope. The 35 mm chamber system uses simple disposable 35 mm tissue dishes making it ideal for cultured cells. A key design feature, this chamber uses magnets to close the chamber… simply insert the dish and close the chamber’s lid. [...]
Lying between single cell and whole heart experimental studies, cardiac slices provide many of the benefits of a reductionist approach of isolated cardiac myocytes while being easier to generate and more robust with added physiological relevance. Cardiac slices, unlike single isolated myocytes, can be used to study cardiac function within a multicellular context and an intact myofilament lattice. Slices have the added benefit of maintaining a syncytium [...]
The CytoMotion Lite system is a low-cost solution offering fast, real-time characterization of contractility kinetics from stem cell-derived cardiomyocytes Acquiring contractility kinetics in human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) derived cardiomyocytes can be especially challenging given their amorphous phenotype and poorer contrast relative to adult ventricular cardiomyocytes. We've made capturing contractility simple and easy. CytoMotion Lite System is a low-cost, simplified [...]
CytoMotion Software Cymotion software - Over the last decade human induced pluripotent stem cells (hiPSCs), as well as human embryonic stem cells (hESCs), have emerged as a model system complementary to classic approaches, suitable for cardiac disease modelling. These stem cells offer important advantages, the most significant of which owing to their human genetic background. Despite their advantages, they are less mature, more amorphous, and provide poorer contrast. [...]
A multi-mode, multi-channel system for mechanical stretching and electrical stimulation of tissue and cells The new IonOptix Culture Pacing System is a multi-mode, multi-channel system for mechanical stretching and/or electrical stimulation of tissue and stem cells. It can be used with our C-Stretch for simultaneous stretch and stimulation or with our C-Dish electrode assemblies and standard culture dishes for electrical stimulation alone. The Culture Pacing System uses [...]
Lying between single cell and whole heart experimental studies, intact papillary muscle isolated from hearts offers unique advantages. Intact Muscle Chamber System - unlike single isolated myocytes, which represent the smallest fully functional model system, intact papillary muscle can be used to study cardiac function within a multicellular context and an intact 3-dimensional myofilament lattice. And unlike whole heart studies, the contractile characteristics of papillary muscle can be [...]
A complete data acquisition system for diameter & fluorescence measurements, as well as flow characterization in pressurized vessels We have equipped our Blood Vessel System for simultaneous measurements of pressurized blood vessel fluorescence and diameter. By visualizing the blood vessel on the microscope, IonOptix’ new vessel-specific dimensioning software, VesAcq, can track the outer and/or luminal diameters, wall thickness and cross-sectional area of the blood vessel from the digitized frame while [...]
Record Force from Isolated Cardiac Myocytes! IonOptix is proud to announce the release of our next generation MyoStretcher System, which now uses our revolutionary New Optical Force Transducer, the OptiForce. Designed specifically for force measurement in cardiomyocytes, it is now the most sensitive system on the market for measuring isolated myocyte force! Easily measure ESFLR and EDFLR. We’ve developed the MyoStretcher with a focus on simplicity, ease-of-use, and [...]
The Multicell High Throughput System is an advanced, fully-automated solution for identification and mechanical phenotype quantification of hundreds of myocytes per hour. The MultiCell HTS system offers high-speed, high-content mechanical myocyte data acquisition from hundreds of myocytes per hour by using our automated cell finding image analysis method. The system includes a fast x-y-z position programmable scanning microscope which can mark and find position, size, focus and orientation [...]
C-Dish The patented* C-Dish™ works with the C-Pace EM chronic cell stimulator to form a complete system for the chronic stimulation of bulk-quantities of cardiac myocytes (and other excitable cells) in culture. The C-Dish™ is a simple, 2-piece assembly that precisely places carbon electrode elements in a variety of standard culture plates. A ribbon cable connector provides access to the field stimulating electrodes. [...]
