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This document contains a step-by-step guide for the hardware configuration of IonWizard 6 under windows XP.
The endothelial response to flow-induced stress (e.g., the generation and secretion of nitric oxide) is an important modulator of vascular tone and function, linking vasodilation and constriction to …
Interest in the physiology and pathology of the circulatory system has led to a substantial increase in the number of laboratories studying isolated and pressurized blood vessels.
Intraluminal Pressure Is a Stimulus for NFATc3 Nuclear Accumulation: ROLE OF CALCIUM, ENDOTHELIUM-DERIVED NITRIC OXIDE, AND cGMP-DEPENDENT PROTEIN KINASEionoptix2019-10-22T18:24:32-05:00
The transcription factor NFAT (nuclear factor of activated T-cells) is implicated in cardiac hypertrophy and vasculogenesis. NFAT activation, reflecting dephosphorylation by the calcium-dependent phosphatase, calcineurin, and subsequent nuclear localization, is generally thought to require a sustained increase in intracellular calcium. However, in smooth muscle we have found that elevation of calcium by membrane depolarization fails to induce an increase in nuclear localization of the NFATc3 isoform. Here, we demonstrate that [...]
Myogenic tone, reactivity, and forced dilatation: a three-phase model of in vitro arterial myogenic behaviorionoptix2019-10-22T18:24:59-05:00
Myogenic behavior, prevalent in resistance arteries and arterioles, involves arterial constriction in response to intravascular pressure. This process is often studied in vitro by using cannulated, pressurized arterial segments from different regional circulations. We propose a comprehensive model for myogenicity that consists of three interrelated but dissociable phases: 1) the initial development of myogenic tone (MT), 2) myogenic reactivity to subsequent changes in pressure (MR), and 3) forced dilatation at [...]
Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.ionoptix2019-10-22T18:25:28-05:00
Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia. Jernigan NL, Walker BR, Resta TC Abstract: Recent evidence supports a prominent role for Rho kinase (ROK)-mediated pulmonary vasoconstriction in the development and maintenance of chronic hypoxia (CH)-induced pulmonary hypertension. Endothelin (ET)-1 contributes to the pulmonary hypertensive response to CH and recent studies by our laboratory and others indicate that pulmonary vascular reactivity following [...]
Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries.ionoptix2019-10-22T18:25:49-05:00
Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries. Zhao G, Adebiyi A, Blaskova E, Xi Q, Jaggar JH Abstract: Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) regulate diverse physiological functions, including contraction and proliferation. Three IP3R isoforms exist, but functional significance of these subtypes in arterial smooth muscle cells is unclear. Here, we investigated relative expression and physiological functions of IP3R isoforms in [...]