Muscle tissue data acquisition
Living myocardial slice work loop preload ramp
ionoptix2026-06-12T12:22:41-05:00A short video showing a work loop with preload ramp in living myocardial slice on the MyoClamp system.
MyoClamp System Highlights
ionoptix2026-06-12T11:58:53-05:00A short video highlighting the MyoClamp system.
Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress (2025)
ionoptix2026-05-15T18:00:38-05:00Pilcher LE, Hancock E, Neeli A, Sckolnick M, Caporizzo MA, Palmer BM, Spees JL (2025). Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress. J Mol Cell Cardiol Plus. 2025 Mar 2;11:100291. doi: 10.1016/j.jmccpl.2025.100291.
Myosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure (2025)
ionoptix2026-05-15T18:01:07-05:00Mohran S, Kooiker KB, Naim A, Pilagov M, Asencio A, Turner KL, Ma W, Flint G, Jiang S, Zhao J, McMillen TS, Mandrycky C, Mahoney-Schaefer M, Irving TC, Tanner BCW, Kad NM, Regnier M, Moussavi-Harami F (2025). Myosin Modulator Aficamten Inhibits Force by Altering Myosin's Biochemical Activity Without Changing Thick Filament Structure. JACC Basic Transl Sci. 2026 Jan;11(1):101449. doi: 10.1016/j.jacbts.2025.101449.
Microtubule destabilization with colchicine increases the work output of myocardial slices (2024)
ionoptix2026-05-15T18:01:38-05:00Hancock EN, Palmer BM, Caporizzo MA (2024). Microtubule destabilization with colchicine increases the work output of myocardial slices. J Mol Cell Cardiol Plus. 2024 Mar;7:100066. doi: 10.1016/j.jmccpl.2024.100066.
Preparing Excitable Cardiac Papillary Muscle and Cardiac Slices for Functional Analyses (2022)
ionoptix2026-05-14T08:46:12-05:00Palmer BM and Bell SP (2022) Preparing Excitable Cardiac Papillary Muscle and Cardiac Slices for Functional Analyses. Front. Physiol. 13:817205. doi: 10.3389/fphys.2022.817205
Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle (2020)
ionoptix2026-05-15T18:02:48-05:00Vetter AD, Martin AA, Thompson BR, Thomas DD, Metzger JM (2020). Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle. J Mol Cell Cardiol. 2020 Oct;147:49-61. doi: 10.1016/j.yjmcc.2020.07.012.
MyoClamp System Handout
ionoptix2026-02-19T13:29:54-05:00Handout describing MyoClamp System features.
MyoClamp System User’s Guide
ionoptix2026-04-22T17:13:08-05:00User's guide for the MyoClamp System for functional data from intact muscle tissue.