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Functional Characterization of Excitation-Contraction Coupling in Cardiomyocytes

Cardiac excitation-contraction coupling is the process by which electrical excitation drives cardiomyocyte mechanical shortening. Understanding this tightly regulated process, as well as how perturbations disrupt it, is critical to understanding heart function and dysfunction.

In this webinar Dr. Joe Soughayer and Dr. Adam Veteto present tools to characterize E-C coupling in isolated adult cardiomyocytes and iPSC-/ESC-derived cardiomyocytes. They describe how these tools work and how they quantify important functional outputs describing the speed and amplitude of calcium release and reuptake, as well as downstream myocyte shortening and relengthening.

Key topics include:

  • What quantitative approaches can you take to understand excitation-contraction coupling?
  • What does characterization of excitation-contraction coupling reveal about cardiac physiology/pathophysiology?

Access the webinar recording below.