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RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells (2025)
ionoptix2026-06-16T18:15:23-05:00Yi N, Wang HR, Zhu YP, Xiao T, Lin Q, Liu H, Meng YL, Sun YZ, Lin F, Hu SY, Cao HM, Zhang JF, Peng LY, Li L. RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells. Stem Cell Res Ther. 2025 Mar 18;16(1):144. doi: 10.1186/s13287-025-04269-7.
Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome (2024)
ionoptix2026-06-16T18:55:06-05:00Busley AV, Gutiérrez-Gutiérrez Ó, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Böhmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Ahmadian MR, Wollnik B, Cyganek L. Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome. Cell Rep. 2024 Jul 23;43(7):114448. doi: 10.1016/j.celrep.2024.114448.
Stretch regulation of β2-Adrenoceptor signalling in cardiomyocytes requires caveolae (2025)
ionoptix2026-05-15T17:57:45-05:00Fu J, Mansfield C, Diakonov I, Judina A, Delahaye M, Bhogal N, Sanchez-Alonso JL, Kamp T, Gorelik J. Stretch regulation of β2-Adrenoceptor signalling in cardiomyocytes requires caveolae. Cardiovasc Res. 2025 Apr 29;121(3):440-453. doi: 10.1093/cvr/cvae265.
Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo (2025)
ionoptix2026-05-15T18:00:08-05:00Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley R, Palanki R, Musunuru K, Brenner JS, Mitchell MJ, Ferrari VA, Mui BL, Semple SC, Weppler SA, Atluri P, Margulies KB, Weissman D, Muzykantov VR. Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2409266122. doi: 10.1073/pnas.2409266122.
MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids (2024)
ionoptix2026-05-15T18:57:47-05:00Desai D, Song T, Singh RR, Baby A, McNamara J, Green LC, Nabavizadeh P, Ericksen M, Bazrafshan S, Natesan S, Sadayappan S. MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids. Cells. 2024 Nov 19;13(22):1913. doi: 10.3390/cells13221913.
Real-Time Measurements of Calcium and Contractility Parameters in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (JOVE VIDEO)(2023)
ionoptix2026-05-27T10:10:01-05:00Real-Time Measurements of Calcium and Contractility Parameters in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Dinani R, Manders E, Helmes M, Wang L, Knollmann B, Kuster DWD, van der Velden J. J Vis Exp. 2023 May 26;(195). doi: 10.3791/65326.
Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress (2025)
ionoptix2026-05-15T18:00:38-05:00Pilcher LE, Hancock E, Neeli A, Sckolnick M, Caporizzo MA, Palmer BM, Spees JL (2025). Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress. J Mol Cell Cardiol Plus. 2025 Mar 2;11:100291. doi: 10.1016/j.jmccpl.2025.100291.
Myosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure (2025)
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Microtubule destabilization with colchicine increases the work output of myocardial slices (2024)
ionoptix2026-05-15T18:01:38-05:00Hancock EN, Palmer BM, Caporizzo MA (2024). Microtubule destabilization with colchicine increases the work output of myocardial slices. J Mol Cell Cardiol Plus. 2024 Mar;7:100066. doi: 10.1016/j.jmccpl.2024.100066.
Preparing Excitable Cardiac Papillary Muscle and Cardiac Slices for Functional Analyses (2022)
ionoptix2026-05-14T08:46:12-05:00Palmer BM and Bell SP (2022) Preparing Excitable Cardiac Papillary Muscle and Cardiac Slices for Functional Analyses. Front. Physiol. 13:817205. doi: 10.3389/fphys.2022.817205
Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle (2020)
ionoptix2026-05-15T18:02:48-05:00Vetter AD, Martin AA, Thompson BR, Thomas DD, Metzger JM (2020). Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle. J Mol Cell Cardiol. 2020 Oct;147:49-61. doi: 10.1016/j.yjmcc.2020.07.012.
Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription.
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