Athlin S, Steger N, Thazhath-Veettil J, Gentile C, Demirel I, Sirsjö A, Kienesberger PC, Nordenskjöld A, Paramel GV. Cardiac spheroids as a human model for inflammation induced cardiac dysfunction. Biofabrication. 2026 Mar 11;18(2). doi: 10.1088/1758-5090/ae4ad7.
RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells (2025)
ionoptix2026-06-16T18:15:23-05:00Yi N, Wang HR, Zhu YP, Xiao T, Lin Q, Liu H, Meng YL, Sun YZ, Lin F, Hu SY, Cao HM, Zhang JF, Peng LY, Li L. RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells. Stem Cell Res Ther. 2025 Mar 18;16(1):144. doi: 10.1186/s13287-025-04269-7.
Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome (2024)
ionoptix2026-06-16T18:55:06-05:00Busley AV, Gutiérrez-Gutiérrez Ó, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Böhmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Ahmadian MR, Wollnik B, Cyganek L. Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome. Cell Rep. 2024 Jul 23;43(7):114448. doi: 10.1016/j.celrep.2024.114448.
MultiCell w CytoMotion highlights
ionoptix2026-06-15T11:53:56-05:00CytoMotion: fast, simple, reliable, real-time functional measurements in iPSC-CMs
Living myocardial slice work loop preload ramp
ionoptix2026-06-12T12:22:41-05:00A short video showing a work loop with preload ramp in living myocardial slice on the MyoClamp system.
MyoClamp System Highlights
ionoptix2026-06-12T11:58:53-05:00A short video highlighting the MyoClamp system.
StimSwitch Cables, Accessories Datasheet
ionoptix2026-06-03T16:07:08-05:00Datasheet for the IonOptix StimSwitch Cables and Accessories
StimSwitch 6-24 Dish Datasheet
ionoptix2026-06-03T16:01:22-05:00Datasheet for the IonOptix StimSwitch 6-24 Dish
Stretch regulation of β2-Adrenoceptor signalling in cardiomyocytes requires caveolae (2025)
ionoptix2026-05-15T17:57:45-05:00Fu J, Mansfield C, Diakonov I, Judina A, Delahaye M, Bhogal N, Sanchez-Alonso JL, Kamp T, Gorelik J. Stretch regulation of β2-Adrenoceptor signalling in cardiomyocytes requires caveolae. Cardiovasc Res. 2025 Apr 29;121(3):440-453. doi: 10.1093/cvr/cvae265.
Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo (2025)
ionoptix2026-05-15T18:00:08-05:00Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley R, Palanki R, Musunuru K, Brenner JS, Mitchell MJ, Ferrari VA, Mui BL, Semple SC, Weppler SA, Atluri P, Margulies KB, Weissman D, Muzykantov VR. Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2409266122. doi: 10.1073/pnas.2409266122.
A new approach to characterize cardiac sodium storage by combining fluorescence photometry and magnetic resonance imaging in small animal research (2024)
ionoptix2026-05-15T18:57:27-05:00Christa M, Dithmar F, Weinaus T, Kohlhaas M, Arias-Loza AP, Hofmann M, Elabyad IA, Gutjahr FT, Maack C, Bauer WR. A new approach to characterize cardiac sodium storage by combining fluorescence photometry and magnetic resonance imaging in small animal research. Sci Rep. 2024 Jan 29;14(1):2426. doi: 10.1038/s41598-024-52377-w.
MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids (2024)
ionoptix2026-05-15T18:57:47-05:00Desai D, Song T, Singh RR, Baby A, McNamara J, Green LC, Nabavizadeh P, Ericksen M, Bazrafshan S, Natesan S, Sadayappan S. MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids. Cells. 2024 Nov 19;13(22):1913. doi: 10.3390/cells13221913.
EGFR/IGF1R Signaling Modulates Relaxation in Hypertrophic Cardiomyopathy (2023)
ionoptix2026-05-15T18:58:02-05:00Algül S, Schuldt M, Manders E, Jansen V, Schlossarek S, de Goeij-de Haas R, Henneman AA, Piersma SR, Jimenez CR, Michels M, Carrier L, Helmes M, van der Velden J, Kuster DWD. EGFR/IGF1R Signaling Modulates Relaxation in Hypertrophic Cardiomyopathy. Circ Res. 2023 Aug 18;133(5):387-399. doi: 10.1161/CIRCRESAHA.122.322133.
Real-Time Measurements of Calcium and Contractility Parameters in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (JOVE VIDEO)(2023)
ionoptix2026-05-27T10:10:01-05:00Real-Time Measurements of Calcium and Contractility Parameters in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Dinani R, Manders E, Helmes M, Wang L, Knollmann B, Kuster DWD, van der Velden J. J Vis Exp. 2023 May 26;(195). doi: 10.3791/65326.
Characterization of heterozygous and homozygous mouse models with the most common hypertrophic cardiomyopathy mutation MYBPC3c.2373InsG in the Netherlands (2023)
ionoptix2026-05-15T18:58:16-05:00Hilderink S, Schuldt M, Goebel M, Jansen VJ, Manders E, Moorman S, Dorsch LM, van Steenbeek FG, van der Velden J, Kuster DWD. Characterization of heterozygous and homozygous mouse models with the most common hypertrophic cardiomyopathy mutation MYBPC3c.2373InsG in the Netherlands. J Mol Cell Cardiol. 2023 Dec;185:65-76. doi: 10.1016/j.yjmcc.2023.10.008.
Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress (2025)
ionoptix2026-05-15T18:00:38-05:00Pilcher LE, Hancock E, Neeli A, Sckolnick M, Caporizzo MA, Palmer BM, Spees JL (2025). Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress. J Mol Cell Cardiol Plus. 2025 Mar 2;11:100291. doi: 10.1016/j.jmccpl.2025.100291.
Myosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure (2025)
ionoptix2026-05-15T18:01:07-05:00Mohran S, Kooiker KB, Naim A, Pilagov M, Asencio A, Turner KL, Ma W, Flint G, Jiang S, Zhao J, McMillen TS, Mandrycky C, Mahoney-Schaefer M, Irving TC, Tanner BCW, Kad NM, Regnier M, Moussavi-Harami F (2025). Myosin Modulator Aficamten Inhibits Force by Altering Myosin's Biochemical Activity Without Changing Thick Filament Structure. JACC Basic Transl Sci. 2026 Jan;11(1):101449. doi: 10.1016/j.jacbts.2025.101449.
Microtubule destabilization with colchicine increases the work output of myocardial slices (2024)
ionoptix2026-05-15T18:01:38-05:00Hancock EN, Palmer BM, Caporizzo MA (2024). Microtubule destabilization with colchicine increases the work output of myocardial slices. J Mol Cell Cardiol Plus. 2024 Mar;7:100066. doi: 10.1016/j.jmccpl.2024.100066.